Celiac Disease and it's Epidemiology
Authors: Dr. B. Shahbazkhani, Dr. N. Aletaha, Dr. A. Pourshams, Dr. R. Malekzadeh
Year of Publications: 2007
Number Of Pages: 183
Price: 67000 Rials
Table of Contents:
Celiac disease (CD) is a common autoimmune disorder, induced by the intake of gluten proteins present in wheat, barley and rye. Contrary to common belief, this disorder is a systemic disease with different manifestation, rather than merely a pure digestive alteration. CD is closely associated with genes that code HLA-II antigens, mainly of DQ2 and DQ8 classes. Previously, it was considered to be a rare childhood disorder, but is actually considered a frequent condition, present at any age. Tissue transglutaminase (tTG), appears to be an important component of this disease, both, in its pathogenesis and diagnosis and follow up,too. Active CD is characterized by intestinal and/or extra-intestinal symptoms, villous atrophy and crypt hyperplasia, and strongly positive anti endomysial antibody or tTG auto-antibodies. The duodenal biopsy is considered to be the “gold standard” for diagnosis. Occasionally, it results in a false-negative because of patchy mucosal changes and the presence of mucosal villous atrophy is often more severe in the proximal jejunum, usually not reached by endoscopic biopsies. Sometimes, the presentation of CD is with iron deficiency anemia, osteoporosis, dermatitis herpetiformis, persistent chronic hypertransaminasemia of unknown origin and neurologic disorder. The association of celiac disease and endocrine diseases, autoimmune disorders and various types of cancer is known. Treatment of CD is a strict, life-long gluten-free diet. Gluten-free diet, results in remission for most symptoms.